The Beta Pi Chapter of Beta Theta Pi, the 46th chapter of Beta Theta Pi to be colonized at a University. The charter for the University of Minnesota Chapter was granted in 1889, and ten founders were initiated into the ranks of Beta Theta Pi:
 

• Victor Seldon Clark
• Milton Rex
• Siver Sirumgard
• William Carpenter Smith
• Charles Leissreing Sommers
• Birney Elias Trask
• George Phillip Huhn
• Horace Randall Robinson
• Thompson Welliver Stout
• John Turner Higgins

The current chapter house at 1625 University Ave. was built in the year 1927 to replace the original house, which was built in 1900 and burned down in 1927. The original house was the second house built on University Ave.’s Fraternity row which was made a historic landmark by the City of Minneapolis in 2003.

An important alumnus to the Minnesota Chapter, Peter F. Greiner served as General Fraternity President from 1966-1972. In honor of his service to the General Fraternity, the leadership development event that occurs every year at the General Convention was named after this Beta Great. He is still honored at his local chapter where a central room is named after this important alumnus.